Ciprofloxacin is a fluoroquinolone antibacterial drug effective in the treatment of bacterial infections. Ciprofloxacin has a short biological half-life of 2-4 hrs; it has been given frequently to maintain effective plasma concentration, which leads to fluctuation in the plasma concentration and resulting in ineffective therapy. In order to maintain effective plasma drug concentration for prolonged period of time and to reduce several dose related side effects, controlled release formulations of Ciprofloxacin loaded with Ethyl cellulose and various grade of hydroxyl propyl methyl cellulose (HPMC) were formulated by the emulsion-solvent diffusion evaporation technique. The various batches of microspheres were characterized to percentage practical yield, particle size, percentage drug entrapment efficiency and in vitro drug release study. The percent drug entrapment of the prepared microspheres was found to be in the range of 62.43-87.21 % indicating the application of the present method for the preparation of microspheres with high content uniformity. In vitro studies showed that microspheres prepared from F5 batch showed best controlled release over a period of 8 hrs than others.
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